Endocrine Abstracts

Gonarthrosis is a severe problem of movement system. It is a restrictive health problem for modern human. And also; it is the other restrictive problem which coexistence of diabetes mellitus (DM) and gonarthrosis. Perhaps; an other parameter that is deserved to research for this coexistence is metabolic syndrome. Today, relationship between this clinical conditions are clear enough. And also two lobotuary parameters as Leptin and Nesfatin-1 are an other headstone for obesity a...

Osteoarthritis is a great public health problem indiscriminately; ie goanrthritis, coxarthritis or dejenerative spine diseases. Osteoarthritis is focude sixth decades in elderly people, espicially in women. Many studies assingned the efficiancy of Diabetes Mellitus in the etiology of Osteoarthritis. Correlations between bone-destructive characteristics and carbohydrate metabolism errors is now quite accused in this clinical views. A comparing between Diabetes Mellitus Type 1 a...

Diaserein is used in the spesific and long-term treatment of degenerative joint diseases (as osteoarthritis). In vitro studies have showed that Diaserein and its active metabolyte Rheinin inhibate production and activity of interleukin-113 (IL-113), some proinflamatuar and pro-catabolic cytokines. Interleukin-113 play important role to trigger production of more pro-inflamatuar factors as cytokines, cyclo-oxygeneas, prostogalandines, nitric oxide, matrix metalloprotei...